• Moreover we cannot completely rule out that MSCs in

  2018-10-22

  

  Moreover, we cannot completely rule out that MSCs in the lungs, where they home to in large numbers immediately after injection, create a pre-metastatic niche for tumor metastasis to develop later. However, the findings by Karnoub et al.(2007) and the time gap between MSC-infiltration and appearance

• Thus various experimental approaches have been undertaken to

  2018-10-22

  

  Thus, various experimental approaches have been undertaken to determine the exact cellular origin of HSCs in different animal models. Constant cell labeling and time-lapse imaging performed during mouse ESC cultures and BL-CFC development have shown that the hemangioblast generates hematopoietic cel

• Introduction Transplantation of autologous or allogeneic hem

  2018-10-22

  

  Introduction Transplantation of autologous or allogeneic hematopoietic stem Cy3.5 maleimide (HSCs) dramatically improved the disease free survival of numerous patients with hematological diseases and presently remains the only widely used cellular transplantation procedure (Deeg and Bartenstein, 2

• br Discussion We have described

  2018-10-22

  

  Discussion We have described an approach that achieves inducible, retrovirus-mediated gene expression by using the coding sequence of TFs fused to an ERT2 motif. Fusion of the ERT2 motif to two TFs that regulate fate-choice decisions in the course of adult neurogenesis (i.e., ASCL1 and NEUROD1) a

• Human PGCs are specified in the

  2018-10-22

  

  Human PGCs are specified in the embryo between the second and third week of life after fertilization. Similar to mice, human PGCs are first localized outside of the embryo, then they migrate into the embryo during week 3, ultimately entering the genital ridges and indifferent gonads between the four

• miRNAs are short non coding RNAs

  2018-10-22

  

  miRNAs are short non-coding RNAs that can modulate gene expression by binding to the complementary sequences on target sites in the 3′ untranslated regions (UTRs) of messenger RNA (Bartel, 2004). There is strong evidence that miRNAs play an important role in the maintenance of ES cells (Pauli et al.

• SCR7 br Cardiac stem cell niches A challenging

  2018-10-20

  

  Cardiac stem cell niches: A challenging task The importance of the niche microenvironment for understanding HSC behavior was acknowledged shortly after the discovery of this adult stem cell class. In the absence of niches, the stemness of the primitive SCR7 cannot be preserved. Outside of their n

• We hypothesized that type B astrocytes might be among the

  2018-10-20

  

  We hypothesized that type B astrocytes might be among the other SVZ-derived cell types able to migrate in response to a damage insult. In this study we used Nilo1, a previously characterized mAb that identifies early neural progenitors in the SVZ niche (Del Valle et al., 2010), demonstrating that Ni

• Oxamflatin Overall ten genes five of which are coding genes

  2018-10-20

  

  Overall, ten genes, five of which are coding genes (FMOD, SULF1, COL12A1, STMN2 and MAEL), and five long-non-coding RNA (lncRNA) genes, were differentially expressed in hUC cells. lncRNAs are non-protein coding transcripts longer than 200 nucleotides. They have been implicated in the regulation of g

• We have examined Oct as a marker for this

  2018-10-20

  

  We have examined Oct4 as a marker for this study because it is well known as a critical factor for maintaining pluripotency, and its expression is lost in differentiated EZ Cap Reagent GG (3\' OMe) (van den Berg et al., 2010; Niwa et al., 2000). The relationship between Oct4 expression and pluripot

• br Materials and methods br Acknowledgements

  2018-10-20

  

  Materials and methods Acknowledgements We would like to thank Michael Majurski, Jing Gao, and Mylene Simon for data processing and web application development. We would also like to thank Steven Lund and James Filliben for help with statistical analysis. MH acknowledges support from the ISAC S

• br Resource table Resource details The study was approved

  2018-10-20

  

  Resource table. Resource details The study was approved by the Singhealth ethics committee (protocol number SHSIBC-2014-031), and written informed consent was obtained from the patient. 2ml of peripheral blood sample was obtained from a male 64-year-old Parkinson\'s disease patient carrying a h

• Although a link between the level of ambient humidity and

  2018-10-20

  

  Although a link between the level of ambient humidity and barrier development has been described in both animals (Hanley et al., 1997; Kömüves et al., 1999) and human premature infants (Agren et al., 2006), and then recapitulated in vitro with NHKs (Thakoersing et al., 2010), the exact molecular mec

• In summary our findings demonstrate a functional requirement

  2018-10-20

  

  In summary, our findings demonstrate a functional requirement for FOXO3 as a regulator of Notch signaling in the self-renewal of SCs during muscle regeneration. These findings add to the growing list of cellular mechanisms that have been studied in the context of the proliferation and differentiatio

• br Introduction The grafting of cultured keratinocytes to

  2018-10-20

  

  Introduction The grafting of cultured keratinocytes to promote regeneration represents one of the oldest clinical examples of stem cell therapy (Green, 2008). The skin constitutes an essential barrier between the living tissues of the body and the external environment, and skin tissues have evolv

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