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br Methods br Results Recruitment
2018-10-23

Methods Results Recruitment ran between July 12, 2010 and June 30, 2011, with follow-up completed on June 30, 2013. Fig. 1 shows the reasons for ineligibility and the flow of participants through the trial. Of 287 patients assessed for eligibility, 86 were randomly assigned: 44 to the telephon
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Because median genetic variation within the Env
2018-10-23

Because median genetic variation within the Env glycoprotein is estimated to be 25% between subtypes (Korber et al., 2001; Gaschen et al., 2002), ADCC-mediating atp gamma s manufacturer must be able to target cells infected with genetically distinct viruses in order to adequately prevent infection.
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glp-1 receptor This study has highlighted the complexity of
2018-10-23

This study has highlighted the complexity of operationally defining compensation in neurodegenerative diseases such as HD. The previous literature in HD has thus far failed to address this issue, instead making assumptions of putative compensation based solely on increased activation or connectivity
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The results of analyses of all included SNPs on
2018-10-23

The results of analyses of all included SNPs on CPD in the WHI SHARe sample are presented in Table 2. In the models with CPD as their outcome in the WHI SHARe cohort, 1 SNP was found to be associated with CPD following Bonferroni adjustment), rs1051730 (adjusted p=0.027). For this SNP, each addition
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However expression of AR was significantly lower in the GG
2018-10-23

However, p53 apoptosis of AR was significantly lower in the GG4 areas of the finasteride group compared to those of the placebo group (). The authors claim that this finding is in accord with an emerging concept that reduced androgens in prostate tissues may, over time, lead to de-repression of AR e
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The earliest studies implied that lab adapted
2018-10-23

The earliest studies implied that lab-adapted SI, presumably CXCR4-using, strains were more neutralization sensitive compared to NSI–CCR5-utilizing variants (Mascola et al., 1996; Montefiori et al., 1998; D\'Souza et al., 1997; Sawyer et al., 1994). Subsequent studies showed that compared to CCR5-ut
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Because of our previous failure
2018-10-23

Because of our previous failure to find an association of graft failure with pretransplant DSA that exclusively reacted in the exquisitely sensitive SAB assay (Susal et al., 2011), we focused in the present study on pretransplant sera containing CDC- or ELISA-reactive antibodies, selected without re
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Macrophages are now regarded as
2018-10-23

Macrophages are now regarded as prominent players in metabolic disorder and associated diseases. Their sub-populations (M1 and M2 macrophages) may have either deleterious or protective functions towards inflammatory regulation depending on certain conditions of various inflammatory microenvironments
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Previous research has described the effects of eight week
2018-10-23

Previous research has described the effects of eight-week mindfulness meditation instruction on neural connectivity (e.g., ), and Shao further extends this work. The Shao study is a note-worthy contribution, especially related to the rigorous randomized active-control study design, longitudinal appr
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This latter study is particularly important in the context o
2018-10-23

This latter study is particularly important in the context of vaccine refusal, since it supports a growing body of research which underscores the role of clusters of non-vaccinators in lowering herd immunity and allowing for disease outbreaks (Salathé and Bonhoeffer, 2008; Liu et al., 2015). The US
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Baseline levels of biomarkers of immune activation and infla
2018-10-23

Baseline levels of biomarkers of immune activation and azd2171 were similar by treatment arm, and there were no differences between treatment groups at weeks 12, 24, or 48 (p>0.05, Supplementary Table 1) for any of the markers, except for IL-6 at week 12 only (median, TAF: 1.4pg per mL, TDF: 1.1pg
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Conflict of Interest br Chronic
2018-10-23

Conflict of Interest Chronic immune activation is a hallmark of HIV infection (). Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine detected throughout the disease course in plasma and lymph nodes of HIV-infected patients. The HIV-1 Nef protein is produced early during the disease
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During gastrulation the temporal and spatial determination
2018-10-23

During gastrulation, the temporal and spatial determination of cell fates in different PS regions towards specific developmental lineages depends on the signalling cues in the surrounding environment. Members of the Transforming Growth Factor Beta (TGFβ) family (including BMP4 and Nodal) (Hogan, 199
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br Human respiratory syncytial virus RSV is
2018-10-23

Human respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infections in infants and young children worldwide and also an important pathogen in elderly. Millions of patients get hospitalized and up to 200,000 children die each year due to an RSV infection (). Des
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Growing concerns about the robustness and reproducibility
2018-10-23

Growing concerns about the robustness and reproducibility of neuroimaging results have recently garnered unanimous attention (Abi-Dargham and Horga, 2016; Blackford, 2017; Lerch et al., 2017; Poldrack et al., 2017). The quest for pragmatically usable biomarkers calls for the rigorous assessment of t
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