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The use of one or more
2023-11-18
The use of one or more of psychotropic medications and hypnotics was associated with a higher risk of falls in the current study. Previous studies have also shown that these medications increase the risk of falls in the geriatric population.25, 26, 27, 28, 29, 30, 31 Clinicians should weigh the risk
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The central problem in amnesia
2023-11-18
The central problem in amnesia developing following impairment of long-term memory consolidation or reconsolidation is a question of the underlying mechanisms, whether it is caused by impairment of retrieval or memory storage mechanisms [3,8,9,[15], [16], [17], [18]]. To answer this question, severa
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br Studies in zebrafish vascular and neural
2023-11-18
Studies in zebrafish: vascular and neural development and the regulation of left–right asymmetry Zebrafish embryos represent an excellent model system to examine vertebrate vascular development. Major advantages of the zebrafish system include its genetic tractability, small size, external fertil
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Over the past decade extensive research has
2023-11-18
Over the past decade, extensive research has been directed toward the discovery of Aurora-selective small-molecule inhibitors. As a result, a handful of Aurora inhibitors has been identified. Among them, 1 (VX-680) and 2 (SNS-314) have entered human clinical trials as pan-Aurora kinase inhibitors (F
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The GRAVY value for a protein is
2023-11-18
The GRAVY value for a protein is calculated as the sum of hydropathy values of all the amino acids, divided by the number of residues in the sequence (Kyte and Doolittle, 1982). According to Kyte and Doolittle (1982) integral membrane proteins typically have higher GRAVY scores than do globular prot
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Roxithromycin br Conflict of interest br Acknowledgments Thi
2023-11-17
Conflict of interest Acknowledgments This work was financially supported by the Fund Project of Sichuan Provincial Department of Education (16ZB0053), the Scientific Research Foundation of Sichuan Agricultural University (No. 06021400) and the China Postdoctoral Science Foundation (No. 2015M58
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br Conflict of interest br
2023-11-17
Conflict of interest Acknowledgement We wish to thank the Program of National Key R&D Program of China (2017YFD0200500) and the Fundamental Research Funds for the Central Universities (KYTZ201604) for partially funding this work. Introduction Chitosan ((1→4)-2-amino-2-deoxy-β-d-glucose) is
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anti fungal Introduction Antimicrobial resistance is a growi
2023-11-17
Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of anti fungal [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and their know
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Sustained release property is also associated with side effe
2023-11-17
Sustained release property is also associated with side effects reduction [16] that could be confirmed by histopathological analyzes. Massive infiltrating inflammatory cells, hyperproliferation of skin layers and keratin pearls, caused by DMBA and croton oil application [32] are attenuated in Imq-lo
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Ultracentrifugation of AD brain was reported to remove
2023-11-17
Ultracentrifugation of AD NMS-873 was reported to remove >99.95% of Aβ, while only reducing seeding capacity by 70% (Langer et al., 2011). This suggests that the most potent seeding Aβ species are relatively small soluble oligomers rather than larger insoluble fibrils. It was also noted that this po
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br Concluding remarks ROP is a
2023-11-17
Concluding remarks ROP is a major cause of childhood blindness in the world. Current pharmacological therapy focus on anti-VEGF strategy, but this strategy is associated with the unintended effects on delayed eye growth and retinal vasculature development of preterm infants. Preclinical studies u
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To our knowledge BAY has not progressed to
2023-11-17
To our knowledge, BAY 60-6583 has not progressed to clinical development and remains to be the only ADORA2B agonist that has been developed.33, 34 Further development of similar compounds would be beneficial in future fibrosis research. One of the limitations of our study is being limited to in vit
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Actin is capable of polymerizing spontaneously
2023-11-17
Actin is capable of polymerizing spontaneously. However, this process is relatively slow and kinetically unfavorable in cells. Formation of ak7 dimers and trimers, which can easily disassemble due to their instability, is a rate-determining step in actin polymerization [5], [6]. The shape and the l
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Matsuzaki et al attempted fertility therapy in a year
2023-11-17
Matsuzaki et al. attempted fertility therapy in a 26-year-old female with secondary amenorrhea and 17OHD who was a Flubendazole heterozygote for delF53/54 and the missense mutation H373L, which has cycle supports this theory. Oocyte dysfunction with decreased granulosa cell activity might also con
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MafB a member of the Maf protein family
2023-11-17
MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in MRS 2179 tetrasodium salt with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveola
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