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As mentioned earlier two different isoforms of TFE have
2022-09-09
As mentioned earlier two different isoforms of TFE3 [16] have been reported viz. the full length (TFE3L) and smaller (TFE3S) without exon 1&2. TFE3S lacks an N-terminal acidic activation domain which is present in TFE3L hence is a dominant negative form of TFE3L [51]. This dominant negative feature
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Species specificity of small molecular
2022-09-09
Species specificity of small molecular GPR40 agonists have been reported by Takeda scientist. In the binding pocket of TM5, a Leu186 in human GPR40/FFA1 is replaced with Phe in rat, resulting in dramatic inter-species GPR40 activity discrepancy in certain scaffolds of small molecular GPR40 agonists.
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Compounds were tested for GPR
2022-09-09
Compounds , were tested for GPR40 activity in a functional assay monitoring calcium flux in CHO bafilomycin a1 autophagy transiently transfected with human GPR40 gene. As shown in , compound was found to be a nanomolar GPR40 agonist, while compound was much less potent than . To explore the struc
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In the FARM motifs of GGPPSs
2022-09-09
In the FARM motifs of GGPPSs, hydrophobic Maraviroc are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP synthase (GGPPS)
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br Conclusion br Introduction Gastric adenocarcinoma GA is
2022-09-08
Conclusion Introduction Gastric adenocarcinoma (GA) is the fifth most commonly diagnosed malignancy and the third most common cause of death due to cancer worldwide. It is a highly aggressive cancer and 5-year survival rate (5YSR) is usually trametinib synthesis might be one of the critical b
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Metal organic frameworks MOFs have emerged
2022-09-08
Metal–organic frameworks (MOFs) have emerged over the past two decades with the potentials to act as promising materials in gas storage, chemical separation, catalyst, magnetism, sensing, and drug delivery etc (Du et al., 2013, Zhou and Kitagawa, 2014). Additionally, the secondary interactions, such
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br Hh Proteins at a Glance Hh family proteins are
2022-09-08
Hh Proteins at a Glance Hh family proteins are evolutionarily conserved morphogens that provide cells with positional information and fate instruction during early embryonic development. After development, Hh ligands contribute to tissue homeostasis and wound healing 1., 2.. Consistent with these
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br Materials and methods br
2022-09-08
Materials and methods Results Discussion Genetic analyses conducted here were based on specific features of PhyChem indexes for nt dimers extracted to generate a numerical sequence representation, which was used to build models for distinguishing HVR1 variants between CIP and MIP. This data
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br Introduction Although effective hepatitis B virus HBV vac
2022-09-08
Introduction Although effective hepatitis B virus (HBV) vaccines are in use worldwide, HBV-related liver diseases are still a major public health concern, causing considerable morbidity and mortality. Approximately 257 million people are currently suffering from chronic hepatitis B and 887,000 de
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It is known that changes in cGMP levels are positively
2022-09-08
It is known that changes in cGMP levels are positively correlated with plant adaptation to environmental stresses. It seems that a novel group of moonlighting kinases with GC activity is particularly involved in response to biotic stress. It was shown that danger-associated molecular pattern (DAMPs)
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Recent evidence suggests that HCA can also mediate antineuro
2022-09-08
Recent evidence suggests that HCA2 can also mediate antineuroinflammatory effects [63]. Studies in this field were initiated when monomethyl fumarate, the metabolite of DMF, was shown to be an agonist of HCA2[5]. DMF at the same time was shown to not only have beneficial effects in the treatment of
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The original Bee Synch methodology now
2022-09-08
The original Bee Synch methodology (now termed Bee Synch I) utilizes a 5-day CIDR, GnRH (GnRH-1) and PGF on day 0, double dose of PGF on day 5, and FTAI with GnRH (GnRH-2) at 66 h after CIDR removal. Cruppe et al. (2014) reported that the inclusion of GnRH on day 0 does not contribute appreciably to
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br Materials and methods br Results shows serum FSH LH
2022-09-08
Materials and methods Results shows serum FSH, LH, oestradiol and progesterone values in the two cycles from day 2 to day 10. Basal values of these hormones on day 2 (before any intervention) were similar in the two cycles. Thereafter, FSH values did not differ significantly between the two c
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Throughout the last few decades
2022-09-07
Throughout the last few decades, evidence has accumulated indicating that NTTs, whose primary location is the cell surface, are subject to a series of regulatory processes of intracellular traffic to and from the membrane (Robinson and Jackson, 2016; Vaughan and Foster, 2013). In addition, lateral m
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In conclusion we show to our knowledge for
2022-09-07
In conclusion, we show, to our knowledge for the first-time, compelling evidence for functional OTR and GHSR crosstalk, which is likely via the formation of a novel OTR/GHSR heterocomplex with important downstream signalling consequences. This OTR/GHSR interaction is poised to play an important phys
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