• br Regulation of plasma ghrelin

  2022-06-17

  

  Regulation of plasma ghrelin concentration As described above, ghrelin is primarily produced in the stomach and secreted into the blood stream. Plasma ghrelin does not significantly differ between chronic heart failure (CHF) patients and controls, although plasma ghrelin level is significantly hi

• SP2509 br Conflict of interest br Introduction Since

  2022-06-17

  

  Conflict of interest Introduction Since its discovery in 1958 [1]the Ca2+-dependent K+ efflux in human red blood SP2509 (RBC) (further referred to as the Gárdos effect) has been extensively studied (see 2, 3for review) and has been helpful in understanding the role of the Ca2+-activated K+ cha

• br Presenilins in protein trafficking proteolysis and degrad

  2022-06-17

  

  Presenilins in protein trafficking, proteolysis and degradation An obvious explanation for the role of presenilins and γ-secretase in protein trafficking and degradation is that many reported γ-secretase substrates are functionally involved in protein transport. For example, members of the mammal

• The significance of A and tau as

  2022-06-17

  

  The significance of Aβ and tau as therapeutic targets is not only derived from pathological evidence of postmortem brain but also from biochemical analysis of cultured human neurons. This is largely based on the induced pluripotent stem cell (iPSC) technology that has been established to study Aβ, t

• In addition several other considerations were made for the

  2022-06-17

  

  In addition, several other considerations were made for the optimization exercise. While the structural features of the endogenous ligands for long-chain fatty AZD8931 receptors suggest obtaining orthosteric agonists with drug-like properties may be challenging, the optimization efforts were committ

• br Author contributions statement P N Y designed the study

  2022-06-17

  

  Author contributions statement P.N.Y. designed the study, analyzed the data and prepared the draft of the manuscript. C.S performed the experiments, analyzed the data and generated Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, Fig. 8. A.K. and S.D. made Supplementary Figs. S1 and S2. D.

• To investigate an involvement of GPR and GPR

  2022-06-17

  

  To investigate an involvement of GPR120 and GPR40 in the enhancement of cell motile activity of MG-63 cells, highly migratory (MG63-R7) T7 Tag Peptide were established from MG-63 cells (Fig. 2A). The expression level of GPR120 gene was significantly higher in MG63-R7 cells than in MG-63 cells, while

• LMWHs are currently recommended for the treatment of VTE

  2022-06-17

  

  LMWHs are currently recommended for the treatment of VTE in patients with cancer. Compared to vitamin K antagonists, LMWHs are more effective in reducing the risk of recurrent VTE without increasing the risk of bleeding [13]. However, a post hoc analysis of this SB 204990 previous study showed no s

• The finding of histamine action on ASICs also raises

  2022-06-16

  

  The finding of histamine action on ASICs also raises the question about possible action of other histamine receptor ligands. In the present work we selected several compounds and performed electrophysiological testing of their action on recombinant homomeric ASIC1a and ASIC2a. Nα-methylhistamine is

• Recent research reveals that human alkyladenine DNA

  2022-06-16

  

  Recent research reveals that human alkyladenine DNA glycosylase (hAAG) is an important protein enzyme which can specifically recognize and excise a variety of alkylated purines and deoxyinosine from DNA [12]. hAAG plays pivotal roles in maintaining genomic integrity, and it is involved in GLP-2 (rat

• br Acknowledgments This work was supported

  2022-06-16

  

  Acknowledgments This work was supported by the Russian Foundation for Basic Research [grant number 16-04-00205], The Russian Science Foundation [grant number 16-15-00235], Czech Academy of Sciences [grant number RVO 61388963], and the Technology Agency of the Czech Republic [grant number TE010200

• Our overall goal is to develop selective compounds

  2022-06-16

  

  Our overall goal is to develop selective compounds for low-affinity/high-capacity transporters inhibitors (i.e. OCT1–3 and PMAT), and provide the field with much needed, specific pharmacological tools to study these transporters. In our initial efforts, we synthesized halogen substituted analogs and

• GIPR genes were not found

  2022-06-16

  

  GIPR genes were not found in any of the available bird genome as well as the genomes of several species of fish (Tables S3 and S4). The genomic neighborhoods surrounding the GIPR genes in species that have them was generally conserved (see Fig. 8), and like GLP2R, those fish that did have a Gipr gen

• Medulloblastoma predominantly occurs in infants and children

  2022-06-15

  

  Medulloblastoma predominantly occurs in infants and children, and is the most-common type of paediatric malignant regadenoson tumour, accounting for about 20% of all childhood brain tumors [63]. According to cancer genomics, medulloblastoma consists of at least 4 distinct subgroups: Hh driven, Wnt d

• Previous researches about ghrelin focused primarily

  2022-06-15

  

  Previous researches about ghrelin focused primarily on gastrointestinal functions [30], energy balance [31], weight [32], and more recently on anxiety [33], [34], [35] and depression [36]. Here, we provided the first demonstration that chronic peripheral or central ghrelin treatment to CUMS rodents

15612 records 386/1041 page Previous Next First page 上5页 386387388389390 下5页 Last page