• GPR is present primarily in

  2022-01-25

  

  GPR119 is present primarily in the pancreas and the intestine. Activation of GPR119 increases insulin, GLP-1, GIP and PYY secretion. GPR119 agonists stimulate insulin release in a glucose-dependent manner. The glucose dependent insulin secretion (GIDS) mechanism makes GPR119 an attractive target for

• Conclusion By generating high quality hypocotyl transcriptom

  2022-01-24

  

  Conclusion By generating high-quality hypocotyl transcriptomes of a jute hypocotyl-defect mutant and its wild-type comprising the largest number of annotated unigenes (39,076), we identified a complete array of structurally and functionally diverse β-galactosidases. Our proposed domain-centric clas

• Based on the previous report

  2022-01-24

  

  Based on the previous report that FXR regulated PEPCK indirectly [20], we speculated that FXR may regulate gluconeogenesis by regulating some key transcription factors associated with gluconeogenesis. Finally, by using HS218 as a probe, we found that FXR binds to PGC-1α promoter and directly regulat

• br Materials and methods br Results and discussion In order

  2022-01-24

  

  Materials and methods Results and discussion In order to identify genes required for photoautotrophic growth, we screened a random insertion mutant library of Synechocystis 6803 and obtained many mutants with impaired photoautotrophic growth. About 6000 random insertion colonies of the mutant

• There have already been many reports on the

  2022-01-24

  

  There have already been many reports on the AFS gene (Beuning et al., 2010, Green et al., 2007, Li et al., 2006, Pechous and Whitaker, 2004, Pechous et al., 2005, Yuan et al., 2007, Yuan et al., 2010) and HMGR gene (Pechous and Whitaker, 2002, Rupasinghe et al., 2001). The recent advances concerning

• To enhance the impact of GD as an immune

  2022-01-24

  

  To enhance the impact of GD2 as an immune target in this cancer, we investigated a novel strategy to upregulate expression on the cell surface of EwS cells by an epigenetic agent, based on the following rationale. Biosynthesis of GD2 and other gangliosides during organ development is driven by stage

• br Conclusion Leukocytes adhesion to endothelial cells is on

  2022-01-24

  

  Conclusion Leukocytes adhesion to endothelial cells is one of the most critical event in the inflammatory response. In presented paper using a relevant model of adhesion we have demonstrated that histamine influence eosinophils adhesion to endothelium. This effect appears to be mediated by H4 his

• Sometime ago we have described diamino triazines as histamin

  2022-01-24

  

  Sometime ago we have described diamino-1,3,5-triazines as histamine H4R ligands,12, 13 and aryl derivatives of the 1,3,5-triazine, which attenuated inflammatory and nociceptive response in vivo in the rodent models of inflammation induced by acetylcholinesterase inhibitor and zymosan. In this work

• Materials and methods br Results br Discussion Since LF

  2022-01-24

  

  Materials and methods Results Discussion Since LF is a protease, rapid and direct purification is critical for production of functional rLF. Although previous investigators improved the rLF quality by simplifying purification steps, avoiding formation of inclusion body, decreasing degradation

• Immunohistochemical analysis of sheep skin

  2022-01-24

  

  Immunohistochemical analysis of sheep skin sections showed that sGC prtotein is expressed in the hair follicles with different location and abundance between white and black sheep skin (Fig. 6). In white sheep skin, Strong sGC positive signal was detected in the upper hair dermal papilla but no posi

• Etoposide VP a semisynthetic podophyllotoxin derivative agen

  2022-01-24

  

  Etoposide (VP-16), a semisynthetic podophyllotoxin derivative agent, is widely used as a chemotherapic treatment for many cancers (Hande, 1998). VP-16 has been known that its activity is mediated by the interaction with topoisomerase II (an ATP-dependent nuclear enzyme) which regulates DNA topology

• Protease Inhibitor Library br Synthetic Antagonists for FFA

  2022-01-24

  

  Synthetic Antagonists for FFA4 To date, only compounds from a single chemical series have been reported as FFA4 ‘antagonists’ (Table 1). ‘Compound 39’ (4-methyl-N-9H-xanthen-9-yl-benzenesulfonamide), now available from commercial vendors as AH-7614, was initially reported as an antagonist at this

• br Conflict of interest br Acknowledgements br

  2022-01-21

  

  Conflict of interest Acknowledgements Introduction Second generation antipsychotic drugs (SGAs) such as olanzapine are widely used in treating individuals with schizophrenia and bi-polar disorder and are increasingly prescribed for other conditions such as anxiety (Pringsheim and Gardner, 2

• (+)-Apogossypol mg One may carefully evaluate the concept pa

  2022-01-21

  

  One may carefully evaluate the concept ‘pancreas derived GLP-1′ as this may dependent on the specificity of the (+)-Apogossypol mg used in immunohistochemistry or radiommunoassays. If either a side-viewing antibody or a C-terminal wrapping antibody raised against GLP-1 is applied one may also ident

• L-690,330 In the second part of this study

  2022-01-21

  

  In the second part of this study, we investigated the influence of GH on the L-690,330 of the ghrelin receptor, GHSR-1a, at the mRNA and peptide levels in cultured whole follicles. Regulation of the expression of GHSR-1a has a key role in the actions of ghrelin in target tissues. Using RT-PCR and W

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