• br Acknowledgments The authors gratefully acknowledge the

  2022-01-13

  

  Acknowledgments The authors gratefully acknowledge the financial support of this study by STCU Project 6052 “Enzyme multibiosensor system for renal dysfunction diagnosis and hemodialysis control”. Furthermore, this study was supported by NASU in the frame of Scientific and Technical Program “Sens

• Metal organic frameworks MOFs have emerged over the

  2022-01-13

  

  Metal–organic frameworks (MOFs) have emerged over the past two decades with the potentials to act as promising materials in gas storage, chemical separation, catalyst, magnetism, sensing, and drug delivery etc (Du et al., 2013, Zhou and Kitagawa, 2014). Additionally, the secondary interactions, such

• Our investigation also showed NAC increased the level of

  2022-01-13

  

  Our investigation also showed NAC increased the level of DAF and might protect HUVECs from complement activation. NAC, an antioxidant/mucous modifier, has displayed benefits in chronic obstructive pulmonary disease. Martinez de Lizarrondo et al [38] provided evidence that the molecular target underl

• All the compounds and were assayed for their potential

  2022-01-13

  

  All the compounds –, , , –, , – and – were assayed for their potential cytotoxicity at a single dose of 10 µM on Huh7 cells. Interestingly, all compounds proved to be non toxic, with the exception of and which exhibited high cellular toxicity and therefore were excluded from further experiments (a

• The vessel wall protein collagen which

  2022-01-13

  

  The vessel wall protein collagen, which becomes exposed to circulating platelets after vascular injuries, is a very strong platelet agonist. It stimulates all relevant platelet activation steps predominantly via the GPVI/FcRγ-chain receptor complex through an immunoreceptor tyrosine-based activation

• In summary we have designed and

  2022-01-13

  

  In summary, we have designed and optimized a new series of 1,4-dioxycyclohexane GPR119 agonists. SAR studies led to the discovery of the preferred molecule that has potent and efficacious GPR119 activity across species. This lead compound exhibited an excellent ADME and safety profile, and demonstr

• br Results and discussion br Conclusion In summary

  2022-01-13

  

  Results and discussion Conclusion In summary, starting from our previous lead glucocorticoid receptor 1, we replaced the 5-nitropyrimidine core with pyrimidopyrimidine to obtain a series of novel compounds as drug candidates of GPR119 agonist for treatment of type 2 diabetes. Some derivatives

• br Acknowledgements This work was

  2022-01-13

  

  Acknowledgements This work was supported by Slovak Academy of Sciences grants VEGA 2/0052/10 and 2/0045/10. Both clinical observations and preclinical studies suggest that hypofunction of -methyl--aspartate (NMDA) receptor is implicated in the pathophysiology of schizophrenia. Thus, therapeuti

• In the present study co administration of

  2022-01-13

  

  In the present study, co-administration of TM (AT1 receptor blocker) and PD (AT2 receptor blocker) were made in ischemic mice to explore the significance of AT2 receptors in cerebral ischemia while blocking central AT1 receptors. Also to prove that AT2 receptors should be free after ischemic injury

• Fmoc-Asp(OtBu)-OH mg EAAT glutamate uptake is driven by the

  2022-01-13

  

  EAAT glutamate uptake is driven by the co-transport of three sodium ions and one proton, as well as the counter-transport of one potassium ion (Fig. 1B). This complex stoichiometry frees up enough energy to permit Fmoc-Asp(OtBu)-OH mg of glutamate into the cell against a steep concentration gradient

• br Conclusion Until recently astrocytes

  2022-01-13

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of Oxaliplatin homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission. In particular, g

• br Investigations br Genetics GLUT

  2022-01-13

  

  Investigations Genetics GLUT1 is a membrane-bound glycoprotein that provides base-rate glucose transport across blood-tissue barriers. It is constituitively expressed in erythrocytes, FR 180204 microvessels and astroglia. The gene exclusively associated with GLUT1 is SLC2A1, located on chromo

• Colorectal cancer CRC is the leading

  2022-01-12

  

  Colorectal cancer (CRC) is the leading cause of cancer deaths in Taiwan and is also a most common cancer in the world (Huang et al., 2012, Jemal et al., 2011). With early detection and treatment in the initial stage, CRC can be recognized as curable in comparison with other malignant tumors (Levin e

• Our observation that glioblastoma tumor cells express

  2022-01-12

  

  Our observation that glioblastoma tumor cells express ETA-R in 6/10 cases contrasts with a recent publication reporting ETB-R expression in these tumors [17]. The reason for the discrepancy between that report and the present study might be due to the fact that glioblastomas with oligodendroglial co

• Hippo signaling is unique in that

  2022-01-12

  

  Hippo signaling is unique in that it does not possess a cognate ligand and receptor system. Instead, numerous upstream sensors that monitor cell morphology, cell polarity, cell-cell contact, and mechanical stress impinge onto the Hippo pathway core kinases, MST, and LATS. This in turn indicates the

15662 records 475/1045 page Previous Next First page 上5页 471472473474475 下5页 Last page