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Under optimized assay conditions very low concentrations pM
2021-05-10
Under optimized assay conditions, very low concentrations (20pM) of [125I]YP20 bound to hCRF1-CHO moreover membranes with high specificity (>95% inhibited by 1μM astressin) and in a membrane protein-dependent manner. Specific binding was selective vs. the hCRF2α subtype because little specific bind
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urotensin ii We also found a significantly
2021-05-10
We also found a significantly inverse correlation of OPRM1 CpG2-4 methylation level with HDL-C in Han male controls. Lipids are known to involve the inflammation pathway, Aβ formation and stability of neuron, whereby their abnormalities have been shown to increase the risk of AD [39], [40], [41]. HD
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This letter reports an ab initio
2021-05-10
This letter reports an ab initio study on the X peaks of PES by including the SO effect. The multiplet split energies are calculated with the SO-MCQDPT2 method [21], and the so-called pole strengths are evaluated to simulate the relative intensities. The results are compared with the experimental PE
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Cholesterol homeostasis is maintained through a tight regula
2021-05-10
Cholesterol homeostasis is maintained through a tight regulation between endogenous de novo synthesis, dietary absorption, utilization and excretion of bile salts. The A 83-01 of cholesterol from the intestine constitutes the central part of cholesterol homeostasis in the body [41]. In particular,
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The mitogen activated protein kinase MAPK family which consi
2021-05-10
The mitogen-activated protein kinase (MAPK) family, which consists of extracellular signal-regulated protein kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun N-terminal kinase (JNK), is involved in the development of NP (Hung et al., 2012, Ji et al., 2009). Recently, Zhuang et al. (2005) demonstrated that t
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From an industrial perspective the low turnover numbers and
2021-05-10
From an industrial perspective, the low turnover numbers and limited substrate scope of α-KG halogenases still represents a significant challenge. However, in light of the fact that currently no chemical processes are available for the selective halogenation of aliphatic carbon centers in complex m
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Importantly MPO is not only a marker of cardiovascula http
2021-05-10
Importantly, MPO is not only a marker of cardiovascular disease but also emerges as a critical mediator of vascular inflammatory disease: Liberated MPO binds to the endothelium in a leukocyte-independent manner, is subsequently taken up by the endothelium and transcytoses and accumulates in the sube
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The effect of ET activity on the
2021-05-10
The effect of ET-1 activity on the development of experimental pulmonary fibrosis has also been examined by other investigators. One study found that repeated administration of Bosentan, an ERA used to treat pulmonary arterial hypertension (PAH), significantly decreased bleomycin-induced pulmonary f
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br Introduction As a serine
2021-05-10
Introduction As a serine proteinase and a sub-family of the chymotrypsin-like proteinase, Glutamyl endopeptidase (GE), which is mainly found in Bacillus species, specifically cleaves negatively charged amino Otilonium Bromide residues (Glu/Asp) (Yokoi et al., 2001). Madsen et al. (Madsen & Qvist
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Crystallographic and NMR based analyses
2021-05-10
Crystallographic and NMR-based analyses have revealed that RINGs and U-boxes have a common mode of interaction with E2s (Fig. 2A). The key structural elements are two loop-like regions, which, in the case of RINGs, coordinate Zn. The loops surround a shallow groove formed by the central α-helix. Tog
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br Role of ALDH Isoenzymes
2021-05-10
Role of ALDH Isoenzymes in Glioma Growth and Invasion ALDH family genes are commonly upregulated in gliomas, indicating ALDH-dependent cell metabolism. Specific ALDH isoenzymes have been detected in high- and low-grade tumors implicated in cell proliferation, maintenance of CSC properties, invasi
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In the pleural exudates which reflect
2021-05-10
In the pleural exudates, which reflect the in vivo conditions, the concentrations of CysLTs and PGE2 were quite similar. However, when cancer Kisspeptin 234 receptor were cultured for 24 h, both analyses of cell culture medium and cell incubations with Ca2+ ionophore showed low levels of CysLTs. In
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Because aspirin and ibuprofen are NSAIDs both cause
2021-05-10
Because aspirin and ibuprofen are NSAIDs, both cause a variety of adverse effects, including stomach ulcers, stomach bleeding, coagulation disorders, Trehalose synthesis and cerebral microbleeds [13]. Moreover, both cause liver damage [10]. Laster [14] reported a patient with pericarditis treated w
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Previously the N glycan in V of
2021-05-10
Previously, the N-glycan in V3 of HXB2, HXB10, LAI and BRU strains was reported to be dispensable for their infectivity to T cell lines, although detailed growth kinetics and experimental conditions were not described 4, 5, 6, 7, 8. The experiments appear to have been done by infection initiated wit
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br Methods Adult male B
2021-05-08
Methods Adult male B6, 129 CRHtklee mice (25–30g at the beginning of the experiments) that were wild-type (CRF1R+/+) and recessive homozygous or knockout (CRF1R−/−) were housed six per cage. Mice were 3–5months old and derived from mating CRF1R+/− breeders (Jackson Laboratory, California). Wild-t
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