• Prolyl hydroxylation is a widely observed

  2020-07-31

  

  Prolyl hydroxylation is a widely observed post translational modification in collagen, an abundant animal protein. The high content (~13% per chain of the triple helical structure) of 4-hydroxyproline (Hyp,O) in collagen, togather with the natural abundance of collagen has led to the estimation that

• As stated above the limited number of

  2020-07-31

  

  As stated above, the limited number of proven CMV pneumonia cases in our series precluded any attempt to establish a diagnostic CMV DNA load cutoff; nevertheless, in light of the data presented herein, a threshold value of 500 IU/ml is unlikely to be discriminative between CMV pneumonia and pulmonar

• br Conflicts of interest br Acknowledgments This research wa

  2020-07-31

  

  Conflicts of interest Acknowledgments This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1A2A2A01004593). Introduction Resistance to Inhibitors of Cholinest

• Many studies have documented that enolase acts as a plasmino

  2020-07-30

  

  Many studies have documented that enolase acts as a plasminogen-binding protein and this interaction is involved in the tissue invasion and pathogenicity of the causative agents (Almeida et al., 2004; Avilan et al., 2000; Marcilla et al., 2007; Mundodi et al., 2008; Vanegas et al., 2007). Furthermor

• Despite the substantial evidences in favour

  2020-07-30

  

  Despite the substantial evidences in favour of the probable mutation of the CDH1 and DDR1 genes in vitiligo, there are not enough and comprehensive studies on the role of these polymorphisms so far, and the results of the previous studies have not been conclusive (Birlea et al., 2011; Kim et al., 20

• br Acknowledgements The work was financially supported by th

  2020-07-30

  

  Acknowledgements The work was financially supported by the National Nature Science Foundation of China (21677126, 21320102007) and Research Center for Air Pollution and Health, Zhejiang University. Introduction Cytochrome P450 monooxygenases (CYPs) are an important biochemical system involved

• Targeting of the colony stimulating

  2020-07-30

  

  Targeting of the colony stimulating factor-1 receptor (CSF-1R) has emerged as a strategy to ablate MDSCs or inhibit their tumor-promoting functions (Manthey et al., 2009; Patel and Player, 2009). CSF-1 is a cytokine frequently produced by several cancers, including melanoma, pancreatic cancer, and b

• The tonic immobility TI response is an innate and reversible

  2020-07-30

  

  The tonic immobility (TI) response is an innate and reversible defensive response characterized by profound physical inactivity and relative lack of responsivity to environmental stimuli (Klemm, 2001, Ratner, 1967). This behavior is shown during situations of extreme, inescapable threat (Gallup, 197

• br Acknowledgments This research was supported by grants

  2020-07-30

  

  Acknowledgments This research was supported by grants from the Ministerio de Ciencia e Innovación (Grants SAF/FEDER 2010-17907; 2013-49076-P), Spain, Red de trastornos adictivos (RETICS RD12/0028//0003, Instituto de Salud Carlos III, Spain) and Fundación Séneca (15405/PI/10, Región de Murcia, Spa

• Thus the genetic tools used in these studies

  2020-07-30

  

  Thus, the genetic tools used in these studies come with certain limitations too, and thus is it too early to rewrite the “Guide to immunometabolism for immunologists” (O’Neill et al., 2016). Clearly more detailed comparative studies will be needed to reconcile some of the contradictory findings in t

• Our study showed that OPRK and OPRM were more methylated

  2020-07-30

  

  Our study showed that OPRK1 and OPRM1 were more methylated in Xinjiang (Northwest China) than Zhejiang (Southeast China) Han Chinese healthy controls. The above region-related methylation changes of OPRK1 and OPRM1 suggested that their DNA methylation could be altered by environmental factors [31].

• The biological reason underlying the

  2020-07-30

  

  The biological reason underlying the association of ChE with metastatic phenomenon, especially micrometastasis, remains unknown. This could represent a highly interesting area of research [18], [27]. Regarding clinical implications of these findings, patients with decreased pre-SRP serum ChE might b

• br Conclusions In this study we identified and

  2020-07-30

  

  Conclusions In this study, we identified and characterized seventeen members of the CLC gene family in tobacco. A phylogenetic analysis indicated that the NtCLC genes were divided into two clades, as was reported for other plant species. The results of our gene structure and conserved motif analy

• Covalent modification of activated RTKs with ubiquitin which

  2020-07-29

  

  Covalent modification of activated RTKs with ubiquitin, which is carried out by a cascade of enzymatic reactions involving E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme) and E3 (ubiquitin ligase), has been well established as a major mechanism for negative regulation of RTK sign

• Nicotine dependence drives the habit of smoking

  2020-07-29

  

  Nicotine dependence drives the habit of smoking, which causes a heavy load of disease and death, as smoking is one of the largest contributors to preventable morbidity and mortality (GBD 2015 Risk Factors Collaborators, 2016; World Health Organization(WHO), 2017). Inhaled nicotine reaches the brain,

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