• For patients with BCC who underwent surgical excision and ha

  2020-07-28

  

  For patients with BCC who underwent surgical excision and had positive surgical margin(s), either reoperation or close follow-up can be options (Kumar et al., 2000; Kumar et al., 2002). This decision depends on the factors like histopathologic pattern, tumour size and location that increases recurre

• br Expression data suggest involvement of additional TRIMs i

  2020-07-28

  

  Expression data suggest involvement of additional TRIMs in heart function Given the complexity of the cardiac function, involved molecular pathways and processes, and the fact that only a few of the TRIMs have thus far been shown to have a cardiac role, we hypothesized that there would be more TR

• br Conclusion The present work describes

  2020-07-28

  

  Conclusion The present work describes the synthesis of 18 naphthoquinonolyl-1,2,3-triazole compounds based on natural product modification with antiplasmodial activity. Lapachol derivatives disclosed higher activity than the natural product. Six of these final modified lapachol 1,2,3-triazole com

• br Acknowledgement br Introduction Human dihydroorotate dehy

  2020-07-28

  

  Acknowledgement Introduction Human dihydroorotate dehydrogenase (hDHODH), a flavin-dependent mitochondrial enzyme involved in de novo QNZ biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases such as rheumatoid arthritis and cancer [1], [2], [3]. Leflunomide

• To directly test the hypothesis that hepatic steatosis

  2020-07-28

  

  To directly test the hypothesis that hepatic steatosis leads to insulin resistance, we studied transgenic mice that overexpress human DGAT enzymes, which catalyze the final step of triacylglycerol (TG) biosynthesis (Buhman et al., 2001), in the liver. We focused on mice overexpressing DGAT2 (Liv-DGA

• BRD4770 br Development and germination of cereal seeds Caryo

  2020-07-28

  

  Development and germination of cereal seeds Caryopses (cereal grains) are the propagation units of many monocot species, such as wheat, triticale, barley and other cereal species. A caryopsis is a type of dry fruit composed of three tissues: the diploid embryo, the triploid endosperm and the mate

• Although the relationship between central and peripheral reg

  2020-07-28

  

  Although the relationship between central and peripheral regulation of CRF signaling is yet to be elucidated, an accumulation of findings indicates independent regulation between central and peripheral CRF signaling. For example, i.c.v. administration of CRF to hypophysectomized rats induced locomo

• In this study we investigated whether the Ednra signaling is

  2020-07-27

  

  In this study, we investigated whether the Ednra signaling is involved in Hoxa9/Meis1-mediated leukemogenesis. We found an upregulation of Ednra in leukemic murine bone marrow (BM) TPMPA overexpressing Hoxa9 and Meis1 compared to cells overexpressing Hoxa9 alone. We showed that overexpression of Edn

• Present study measured only baseline

  2020-07-27

  

  Present study measured only baseline (preirradiation) levels of PARP-1 and DNA-PK expression. Due to study design, changes in these proteins that might occur during radiotherapy cannot be described. However, previous in vitro study has shown that there is a radiation-induced increase in the activity

• Ivacaftor receptor Increased knowledge about CRC pathogenesi

  2020-07-27

  

  Increased knowledge about CRC pathogenesis has provided new and remarkable treatments beyond the classical options of surgery, radiation and chemotherapy [11]. Despite these advances, chemotherapy remains the most important element of anti-cancer therapy. Chemotherapy, when initiated, is generally e

• br Acknowledgments The authors thank Elisabete Lepera and

  2020-07-27

  

  Acknowledgments The authors thank Elisabete Lepera and Rosana Silva for technical support. The study was supported by FAPESP, CNPq and PADC/FCF-UNESP. T.T. Miguel was the recipient of a FAPESP (Proc. 05/05171-1) and R.L. Nunes-de-Souza of a CNPq (Proc. 303580/2009-7) fellowship. Introduction

• By live imaging of GUL GFP we

  2020-07-27

  

  By live imaging of GUL-1-GFP, we observed the kinetics of aggregate movement within the cell. One of the marked characteristics of GUL-1-GFP cytosolic (but not nuclear-associated) aggregate motion was a “comet-like” movement that was found to be dependent on the presence of properly polymerized micr

• Haplotype CG of rs rs was reported

  2020-07-27

  

  Haplotype CG of rs4633-rs4680 was reported to be significantly higher in controls (p an in patients with endometrial cancer (Hirata et al., 2008), where endometrial cancer tissues with genotype CC of rs4633 and genotype GG of rs4680 had relatively higher COMT pac 1 than samples with genotype TT of r

• Long stretches of ssDNA have also been observed

  2020-07-25

  

  Long stretches of ssDNA have also been observed in rad53-1 mutant 5,7-dihydroxychromone under replication stress using EM images (Sogo et al., 2002). Deletion of EXO1, a 5′-to-3′ exonuclease, can suppress the generation of ssDNA detected in rad53-1 mutant cells (Cotta-Ramusino et al., 2005). It was

• Physiological changes induced by CRF

  2020-07-25

  

  Physiological changes induced by CRF are mediated through CRF1 and CRF2 receptors (Chang et al., 1993, Lovenberg et al., 1995). Previous findings with CRF1 receptor antagonists showed that activation of CRF1 receptor is involved in maternal separation-induced ultrasonic vocalizations (Kehne et al.,

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