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Eleutherococcus senticosus Rupt Maxim Maxim is
2019-07-17
Eleutherococcus senticosus (Rupt. & Maxim.) Maxim is a shrub belonging to the Araliaceae, which is commonly distributed in China, Korea, Japan and Russia. It has been traditionally used as folk medicine for the treatment of rheumatism, diabetes, and hepatitis (Nan et al., 2004). Recent phytochemical
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The changes in the chemokine receptors CCR
2019-07-17
The changes in the chemokine receptors CCR-5 and CXCR-4 in women and men with PTSD are completely different. In the group of women with PTSD alone the level of this Cy7 carboxylic acid (non-sulfonated) to increased six times, whereas, in women with APD and PTSD, the level of the receptor CCR-5 was
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These evidence prompted us to
2019-07-17
These evidence prompted us to investigate the effectiveness of CT-133, a newly discovered, well-tolerated, selective and potent CRTH2 antagonist, as a treatment of ALI. CT-133 has shown a potential response in treating chronic obstructive pulmonary disease (COPD), allergic rhinitis and Cryptotanshin
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Findings from the present study indicate
2019-07-16
Findings from the present study indicate that CRF1 receptors are especially important in fear acquisition. CP154,526 given before acquisition training, at least partly, reinstated the fear-potentiated startle response and blocked the development of contextual conditioned fear in SERT−/− rats. CP154
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Under optimized assay conditions very low concentrations
2019-07-16
Under optimized assay conditions, very low concentrations (20pM) of [125I]YP20 bound to hCRF1-CHO Cilnidipine where membranes with high specificity (>95% inhibited by 1μM astressin) and in a membrane protein-dependent manner. Specific binding was selective vs. the hCRF2α subtype because little speci
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br Conclusion br Acknowledgement The project was supported b
2019-07-16
Conclusion Acknowledgement The project was supported by National Natural Science Foundation of China, China (No. 31872535); Natural Science Foundation of Shandong Province, China (ZR2018MC027, ZR2016CQ29); and Funds of Shandong \"Double Tops\" Program, China. Introduction High-altitude hyp
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Fujimoto et al pointed out that
2019-07-16
Fujimoto et al. pointed out that RPN2 knockout alleviated the resistance of GC Methotrexate (MKN74 and KATO III) to docetaxel and DDP [23]. Yuan et al. demonstrated that the depletion of RPN2 resulted in the reduction in resistance of GC cells to drugs such as irinotecan, docetaxel, doxorubicin, ox
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Fmoc-L-Arg(Aloc)2-OH br Competing interests br Acknowledgmen
2019-07-16
Competing interests Acknowledgments This work was supported by grants from Fujian Fujian Provincial Natural Science Foundation (2016J01612). Introduction Cancer is still one of the most serious diseases in the world. According to the World Health Organization (WHO), cancer is the second mo
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One of the isolated interactors against Mulan Ube E fusion
2019-07-16
One of the isolated interactors against Mulan259–352–Ube2E3 fusion bait was found to be the GABARAP protein, a known member of the Atg8 family that includes LC3 [20]. The Atg8 family-of-proteins are major players in autophagy/mitophagy since they are part of the autophagosome [20], [21], [22]. Our s
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ICT is a product of icariin
2019-07-16
ICT is a product of icariin via the metabolism of intestinal bacteria with estrogen-like activities [33]. ICT as a bone-protecting agent can enhance osteoblast differentiation while suppressing osteoclastic differentiation in vitro [19], and stimulate osteogenic differentiation and inhibit adipogene
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Diabetic retinopathy is a chronic
2019-07-16
Diabetic retinopathy is a chronic inflammatory disease. Local inflammation plays a pivotal role in the pathological development and progression of this disease [24]. In addition to TNF-α, several other cytokines, chemokines, and other factors such as IL-1β, IL-6, and C-reactive protein have been ind
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phorbol myristate acetate is br Concluding remark br Acknowl
2019-07-16
Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human phorbol myristate acetate is daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes
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br Materials and methods br Results In the leaves
2019-07-16
Materials and methods Results In the leaves of the studied varieties, one to three nucleoli per nucleus were observed (Fig. 1a), except for the variety Bastardo were a maximum of two nucleoli per nucleus were detected. In the root-tip cells, most of the varieties presented one to three nucleo
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br Thy nephritis is one of the most commonly used
2019-07-15
Thy1.1 nephritis is one of the most commonly used models to study the course of immunoglobulin A and other mesangioproliferative nephropathies. To date, most of the studies have focused on mesangial and, to a lesser extent, endothelial cell recovery following capillary damage, whereas data concern
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alvocidib br Materials and methods br Results br Discussion
2019-07-15
Materials and methods Results Discussion Innate immunity plays an essential role in the control and elimination of bacterial infection through production of inflammatory cytokines (Liu et al., 2015). Production of inflammatory cytokines requires the recognition of bacterial pathogen-associa
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