• The findings of recent investigations have suggested that ca

  2018-11-06

  

  The findings of recent investigations have suggested that caloric restriction prevents age-related neuronal damage and may be useful in the prevention and treatment of AD [14]. Hypotheses linking caloric restriction to cognitive capability include anti-inflammatory mechanisms, reduction of neural ox

• br Material and methods br

  2018-11-06

  

  Material and methods Introduction The stem cell niche concept was first proposed more than three decades ago for the human hematopoietic system (Lin, 2002). In the following the stem cell niche concept has also been proposed for several other tissues including the epidermis, the intestinal epi

• br Materials and methods The International Guiding Principle

  2018-11-06

  

  Materials and methods The International Guiding Principles for Animal Research, as stipulated by the World Health Organization (1985) (Howard-Jones, 1985) and as adopted by the Laboratory Animal Center, Shandong University were followed. All efforts were made to reduce the number of mice and thei

• We use the term branching process slightly

  2018-11-06

  

  We use the term branching process slightly differently from the way it is employed in traditional branching process theory in which all branches have independent branching probabilities (Harris, 1963). We apply the term in the context of a single limited system within which processes are embedded, i

• Importantly our findings define a

  2018-11-06

  

  Importantly, our findings define a role for NCPCs in promoting skin repair. How then do NCPCs regulate skin repair? Based upon work in Atglistatin cost (Kumar and Brockes, 2012), we propose that following injury, nerve-derived, Sox2-positive NCPCs proliferate and migrate together with adjacent mese

• Main Text On behalf of

  2018-11-06

  

  Main Text On behalf of the International Society for Stem Cell Research (ISSCR) and the Stem Cell Reports’ editorial team, we would like to extend a warm welcome to you and present the inaugural issue of our journal, Stem Cell Reports. Stem Cell Reports is the ISSCR’s new journal, a highly visible

• miRNAs are short non coding RNAs

  2018-11-06

  

  miRNAs are short non-coding RNAs that can modulate gene expression by binding to the complementary sequences on target sites in the 3′ untranslated regions (UTRs) of messenger RNA (Bartel, 2004). There is strong evidence that miRNAs play an important role in the maintenance of ES cells (Pauli et al.

• HSF which negatively regulates OCT expression upon heat shoc

  2018-11-06

  

  HSF1, which negatively regulates OCT4 expression upon heat shock, has been shown to be important for the development of extraembryonic lineages (Xiao et al., 1999). We thus examined alteration of mRNA expression levels of 1) 21 genes involved in the trophectoderm development (the genes with GOBPs of

• In this report we directly compared

  2018-11-06

  

  In this report we directly compared two cell types to provide a hematopoietic stem/progenitor cell niche in a human system. Many authors have reported the ability of MSCs to expand the HSCs or CD34+ cells. However our flow cytometric studies demonstrated that the majority of the CD34+ order Microcys

• Cancer stem progenitor cells CSPCs are thought of

  2018-11-06

  

  Cancer stem/progenitor A-366 (CSPCs) are thought of as a confounding factor for carcinogenesis and cancer progression because of their capacity for unlimited self-renewal. Studies have shown that several glycoproteins, namely CD133 (Baba et al., 2009; Chen et al., 2014), CD117 (Luo et al., 2011), CD

• Although the concept of direct

  2018-11-06

  

  Although the concept of direct interference with the genetic and molecular foundation of cardiac order 740 Y-P is simple and elegant, myocardial gene transfer is difficult to achieve as a clinical reality. While the use of certain vectors ensures durable release of VEGF without genome integration, t

• br Acknowledgments br This work was supported by the

  2018-11-06

  

  Acknowledgments This work was supported by the National Institutes of Health grant 5UO01DK089569-05 (Beta Cell Biology Consortium/M.G.) and The Leona M. and Harry B. Helmsley Charitable Trust grant 2012PG-T1D010 (M.G.) Introduction Astrocytes are the most abundant cell type in the human bra

• In order to assess the

  2018-11-06

  

  In order to assess the cellular proliferation potential colony forming efficiency was determined. As we decided to apply a low suction vacuum pressure in order to minimize potential discomfort during bone marrow harvest under local anesthesia in the control individuals the achieved mean cell yields

• Subsequently we confirmed that the

  2018-11-06

  

  Subsequently, we confirmed that the gene modified clone of H256 C6, termed CHMP2B IVS5AS GG-CC, remained truly pluripotent. This was demonstrated via expression analyses of key pluripotency markers on protein level (Fig. 1B). Additionally, CHMP2B IVS5AS GG-CC retained the potential to differentiate

• Cell transplantation therapy is a promising approach to

  2018-11-06

  

  Cell transplantation therapy is a promising approach to promote remyelination in MS patients; human embryonic stem luliconazole (hESCs) and induced pluripotent stem cells, as well as fetal brain, are potential sources of therapeutic cells (Brüstle et al., 1999; Müller et al., 2006). Studies in anim

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